Inhibition of abnormal cell proliferation with camptothecin...

A - Human Necessities – 61 – K

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A61K 31/437 (2006.01) A61K 31/4745 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2404970

A method for treating diseases associated with abnormal cell proliferation comprises delivering to a patient in need of treatment a compound selected from the group consisting of 20(S)-comptothecin, analog of 20(S)-comptothecin, derivative of 20(S)-camptothecin, prodrug of 20(S)-camptothecin, and pharmaceutically active metabolite of 20(S)-camptothecin, in combination with an effective amount of one or more agents selected form the group consisting of alkylating agent, antibiotic agent, an alkylating agent, antibiotic agent, antimetabolic agent, hormonal agent, plant-derived agent, anti-angiogenesis agent and biologic agent. The method can be used to treat benign tumors, malignant or metastatic tumors, leukemia and diseases associated with abnormal angiogenesis.

L'invention concerne une méthode de traitement de maladies associées à une prolifération cellulaire anormale. Cette méthode consiste à administrer à un patient nécessitant un tel traitement un composé choisi dans le groupe constitué par une 20(S)-camptothécine, un analogue de 20(S)-camptothécine, un dérivé de 20(S)-camptothécine, un promédicament de 20(S)-camptothécine et un métabolite pharmaceutiquement actif de 20(S)-camptothécine, en combinaison avec une dose efficace d'un ou de plusieurs agents choisis dans le groupe constitué par un agent d'alkylation, un agent antibiotique, un agent antimétabolique, un agent hormonal, un agent dérivé d'une plante, un agent anti-angiogenèse et un agent biologique. Ladite méthode peut être utilisée pour traiter des tumeurs bénignes, des tumeurs malignes ou métastatiques, une leucémie et des maladies associées à une angiogenèse anormale.

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