A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/585 (2006.01) A61P 3/04 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2732266
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted C5 or C6 heteroaryl or heterocycloalkyl ring and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. Specifically, methods and compounds for the treatment of disorders including neurologic, neuropsychiatric, and metabolic disorders are provided. For example, a method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes selecting a subject with or at risk of developing depression, anxiety, or obesity, and administering to the subject a therapeutically effective amount of the described compounds. A further method of promoting neuroprotection in a subject is provided, which includes selecting a subject in need of neuroprotection, and administering to the subject a therapeutically effective amount of the described compounds.
La présente invention concerne de nouveaux composés et procédés permettant dactiver le récepteur TrkB. Les procédés comprennent ladministration in vivo ou in vitro dune quantité thérapeutiquement efficace dun composé contenant quatre cycles à six chaînons et un cycle hétéroaryle ou hétérocycloaryle C5 ou C6 substitué ou non substitué et des sels pharmaceutiquement acceptables, des promédicaments, et leurs dérivés. En particulier linvention concerne des procédés et des composés pour le traitement de troubles comprenant des troubles neurologiques, neuropsychiatriques, et métaboliques. Par exemple, linvention concerne un procédé de traitement et de réduction de risque de dépression, danxiété, ou dobésité chez un sujet, comprenant la sélection dun sujet atteint ou à risque de développer une dépression, lanxiété, ou lobésité, et ladministration au sujet dune quantité thérapeutiquement efficace des composés selon linvention. Linvention concerne également un autre procédé pour promouvoir la neuroprotection chez un sujet, comprenant la sélection dun sujet qui a besoin de neuroprotection, et ladministration au sujet dune quantité thérapeutiquement efficace des composés selon linvention.
Borden Ladner Gervais Llp
Emory University
LandOfFree
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