Chelating agents for attaching metal ions to proteins

Details Chelating agents for attaching metal ions to proteins Chelating agents for attaching metal ions to proteins

C - Chemistry, Metallurgy

07

C

260/179, 167/37,

C07C 331/28 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07C 233/43 (2006.01) C07C 233/54 (2006.01) C07C 245/20 (2006.01) C07D 211/56 (2006.01) C07F 5/00 (2006.01) C07F 13/00 (2006.01) C07K 2/00 (2006.01) C07K 16/00 (2006.01) G01N 33/533 (2006.01)

Patent

CA 2033086

CHELATING AGENTS FOR ATTACHING METAL IONS TO PROTEINS ABSTRACT OF THE DISCLOSURE A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of metal ions and to yield a high metal ion concentration per protein molecule. Using these methods polymeric analogs of these bifunctional chelating agents called Starburst ligands can also be obtained. Protein metal chelates thus obtained will have useful radiophysical, chemical, fluorescent, photochemical and magnetic properties suitable for biomedical applications.

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