Small organic molecules that increase the activity of...

Details Small organic molecules that increase the activity of... Small organic molecules that increase the activity of...

C - Chemistry, Metallurgy

07

D

C07D 295/205 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/4453 (2006.01)

Patent

CA 2500200

Small organic molecules capable of effecting a "pharmacological trabeculocanalotomy" in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.

L'invention concerne de petites molécules organiques pouvant effectuer une <=trabéculocanalotomie pharmacologique>= dans un oeil, par le biais de la réduction du maillage juxtacanaliculaire servant de barrière à l'écoulement vers l'extérieur de l'humeur aqueuse. Ces petites molécules organiques permettent d'augmenter l'activité de la gélatinase A dans des cellules oculaires, par le biais de l'augmentation de l'expression membranaire cellulaire de métalloprotéinases matricielles de type membranaire (MT-MMP) pour augmenter l'écoulement vers l'extérieur de l'humeur aqueuse, en tant que traitement pour un glaucome à angle ouvert primaire.

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