Orally-administered agent

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/24 (2006.01) A61K 9/48 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2738891

An orally-administered agent is provided. The orally-administered agent comprises an intestinal medicine-containing layer containing a medicine to be released in intestines and having surfaces; intestinal collapse-controlling layers provided directly or through an arbitrary layer on the surfaces of the intestinal medicine-containing layer, respectively, at least a part of the intestinal collapse-controlling layers being collapsed in the intestines, and each of the intestinal collapse-controlling layers having a surface opposite to the intestinal medicine-containing layer; and gel-forming layers provided directly or through an arbitrary layer on the sides of the surfaces of the intestinal collapse-controlling layers, respectively, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The intestinal collapse-controlling layers are constituted of a material containing an enteric material to be dissolved by being in contact with a body fluid in the intestines. The orally-administered agent according to the present invention can be swallowed with ease and can release a medicine at intended parts of a living body (in particular, within intestines).

L'invention concerne une préparation orale comprenant : une couche contenant un médicament entérique qui contient ledit médicament destiné à être libéré dans l'intestin ; des couches de contrôle de désintégration entérique qui sont respectivement disposées sur les deux surfaces de la couche contenant le médicament entérique, directement ou par le biais dune couche quelconque, et peuvent être désintégrées au moins partiellement dans l'intestin ; et des couches filmogènes qui sont respectivement disposées sur les couches de contrôle de désintégration entérique, directement ou par le biais dune couche quelconque, et peuvent se gonfler après absorption d'eau pour former un gel. Les couches de contrôle de désintégration entérique contiennent un matériau entérique qui peut être dissous par contact avec un liquide organique dans l'intestin. La préparation orale est facile à avaler, et peut libérer le médicament dans une zone souhaitée (particulièrement l'intestin) d'un organisme vivant.

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