Use of focused light scattering techniques in biological...

G - Physics – 01 – N

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G01N 21/47 (2006.01) G01N 21/25 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2733296

Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.

La présente invention a pour objet des procédés dutilisation de techniques de diffusion de lumière focalisée pour la détection optique de particules biologiques en suspension dans un milieu liquide. La détection optique permet de caractériser la taille et/ou la distribution des particules dans un échantillon donné. Ceci permet à son tour didentifier les particules biologiques, de déterminer leur densité de particules relative, de détecter la diffusion des particules, et didentifier lagrégation des particules. Les procédés sont également utiles dans le criblage et loptimisation de candidats médicaments, lévaluation des niveaux defficacité et de dose de ces médicaments, et dans des applications médicales personnalisées.

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