Cyclopeptide derivatives

Details Cyclopeptide derivatives Cyclopeptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2301182

Compounds of formula (I), in which X, A, B and C have the meanings given in Claim 1, as well as their salts, can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, in pathological conditions maintained and propagated by angiogenesis, and for tumour therapy.

L'invention concerne des composés de la formule (I) dans laquelle X, A, B et C ont la signification mentionnée dans la revendication 1. L'invention concerne également leurs sels et peuvent s'utiliser comme inhibiteurs d'intégrine, notamment pour assurer la prophylaxie et le traitement d'affections de la circulation, en cas de thrombose, d'infarctus, de maladies cardiaques coronariennes, d'artériosclérose, en cas de phénomènes pathologiques entretenus ou propagés par angiogenèse et dans la thérapie tumorale.

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