Process for preparation of a sterile suspension of...

Details Process for preparation of a sterile suspension of... Process for preparation of a sterile suspension of...

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2481520

A process for the preparation of aqueous suspensions of sterile micronized drug particles, in particular corticosteroid, to be administered by inhalation, which produces homogenous dispersions of particles characterised by optimal size and size distribution is disclosed. The process is carried out by using a turboemulsifier equipped with a high-power turbine and connected to a loading hopper.

La présente invention concerne un procédé de préparation de suspensions aqueuses de particules médicamenteuses micronisées, stériles, notamment de corticostéroïdes, destinées à être administrées par inhalation. Ledit procédé permet d'obtenir des dispersions homogènes de particules caractérisées par une dimension et une répartition granulométrique optimales. Ledit procédé consiste à utiliser un turboémulseur équipé d'une turbine haute puissance et relié à une trémie de chargement.

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