Substituted fused heterocyclic compounds

Details Substituted fused heterocyclic compounds Substituted fused heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2305807

Described is a substituted fused heterocyclic compound which is represented by the following formula: Image [wherein R1 represents a group of the following formula: Image (in which R4: a substituted phenyl or a pyridyl which may have a substituent, R5: a hydrogen atom or the like, R6: a hydrogen atom, a C1-6 alkyl group or the like, D: an oxygen or sulfur atom, E: a CH group or a nitrogen atom, R2: a hydrogen atom or the like, R3: a 2,4-dioxothiazolidin-5-ylmethyl group or the like; A: a C1-6 alkylene group, and B: an oxygen or sulfur atom] or a pharmacologically acceptable salt thereof; and has excellent insulin-resistance improving action, lipid-peroxide-production inhibitory action, 5-lipoxygenase inhibitory action and the like.

Des composés hétérocycliques condensés substitués de formule générale (I) ou leurs sels pharmaceutiquement acceptables sont excellents en ce qui concerne leurs effets d'amélioration de la résistance à l'insuline, d'inhibition de la 5-lipoxygénase et de suppression de la formation de peroxydes lipidiques, formule dans laquelle R<1> est représenté par la formule générale (II) où R<4> désigne un phényle substitué ou un pyridyle éventuellement substitué; R<5> désigne un hydrogène, etc.; R<6> désigne un hydrogène, un alkyle en C1-C6, etc.; D désigne un oxygène ou un soufre; et E désigne un groupe porteur d'un CH ou un azote; R<2> désigne un hydrogène etc.; R<3> désigne un 2,4-dioxothiazolidine-5-ylméthyle etc.; A désigne un alkylène en C1-C6; et B désigne un oxygène ou un soufre.

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