Mitotic kinesin inhibitors

A - Human Necessities – 61 – K

Patent

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A61K 31/165 (2006.01)

Patent

CA 2595130

The present invention relates to fluorinated aminoalkyl-4-oxo-3,4- dihydropyrido[3,4-d]pyrimidine derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des dérivés d'aminoalkyl-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine fluorés qui sont utilisés dans le traitement de maladies prolifératives cellulaires, de troubles associés à l'activité de la kinésine KSP et dans l'inhibition de la kinésine KSP. Cette invention a aussi pour objet des compositions qui renferment ces composés et leurs méthodes d'utilisation dans le traitement du cancer chez les mammaliens.

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