Cyclohexylamine derivative as subtype selective nmda...

Details Cyclohexylamine derivative as subtype selective nmda... Cyclohexylamine derivative as subtype selective nmda...

C - Chemistry, Metallurgy

07

C

C07C 215/54 (2006.01) A61K 31/137 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61P 25/16 (2006.01) C07C 215/56 (2006.01) C07C 215/64 (2006.01) C07C 217/16 (2006.01) C07C 217/60 (2006.01) C07C 217/62 (2006.01) C07C 233/23 (2006.01) C07C 235/22 (2006.01) C07C 271/24 (2006.01) C07C 323/25 (2006.01) C07D 213/38 (2006.01)

Patent

CA 2406272

Described are compounds of Formula I and Formula II and their pharmaceutically acceptable salts. The compounds of Formulas I and II are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's disease.

L'invention concerne des composés correspondant aux formules (I) et (II), ainsi que des sels de ceux-ci, acceptables sur le plan pharmacologique. Ces composés, correspondant aux formules (I) et (II), constituent des antagonistes des complexes canalaires récepteurs NMDA (N-méthyl D-aspartate) et sont utiles dans le traitement des troubles cérébro-vasculaires, tels que, par exemple, l'ischémie cérébrale, l'arrêt cardiaque, l'ictus et la maladie de Parkinson.

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