Method of controlling differentiation of embryonic stem (es)...

Details Method of controlling differentiation of embryonic stem (es)... Method of controlling differentiation of embryonic stem (es)...

C - Chemistry, Metallurgy

12

N

C12N 5/0797 (2010.01) C12N 5/0735 (2010.01) A61K 35/30 (2006.01)

Patent

CA 2411914

ES cells have a natural tendency to differentiate into cells resembling those of the extra-embryonic endodermal lineages in the early human embryo. Applicants have found that culturing ES cells in the presence of direct and/or indirect antagonists of the BMP-mediated default pathway of extra-embryonic endoderm differentiation will prevent ES cells from proceeding along this pathway.

Les cellules souches embryonnaires (cellules ES) présentent une tendance naturelle à se différencier en cellules ressemblant à celles des lignées endodermales extra-embryonnaires dans l'embryon humain au stade très précoce. On a découvert que la culture de cellules ES en présence d'antagonistes directs et/ou indirects de la voie par défaut induite par la BMP d'un endoderme extra-embryonnaire, la différenciation pourrait permettre d'empêcher la progression des cellules ES le long de la voie.

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