Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

C - Chemistry, Metallurgy

07

D

C07D 233/02 (2006.01) A61K 31/4709 (2006.01) A61K 31/55 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 221/02 (2006.01) C07D 233/04 (2006.01) C07D 233/54 (2006.01) C07D 235/02 (2006.01) C07D 249/00 (2006.01) C07D 249/16 (2006.01) C07D 257/04 (2006.01) C07D 257/10 (2006.01) C07D 271/02 (2006.01) C07D 271/04 (2006.01) C07D 271/08 (2006.01) C07D 285/02 (2006.01) C07D 285/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 403/02

Patent

CA 2294530

Disclosed are quinoline and benzazepine derivatives that inhibit farnesylprotein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.

La présente invention concerne des dérivés de quinoléine et de benzazépine qui inhibent la farnésyl protéine transférase (FTase) et la farnélysation de la protéine oncogène Ras. Les composés sont utilisés comme agents anti-cancer. Les composés sont également utilisés dans le traitement de maladies autres que le cancer.

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