Cns active fused bicycloheterocycle substituted azabicyclic...

Details Cns active fused bicycloheterocycle substituted azabicyclic... Cns active fused bicycloheterocycle substituted azabicyclic...

C - Chemistry, Metallurgy

07

D

C07D 451/08 (2006.01) A61K 31/4375 (2006.01) A61P 25/00 (2006.01) C07D 451/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2647830

The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

L'invention concerne des dérivés d'alcanes azabicycliques substitués à bicyclohétérocycle fusionné, des compositions comprenant de tels composés, et des procédés de traitement de troubles et d'états pathologiques faisant intervenir de tels composés et de telles compositions.

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