Genetically engineered immunoglobulins

Details Genetically engineered immunoglobulins Genetically engineered immunoglobulins

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/445 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2047244

Immunoglobulins which have been genetically engineered to express a predefined peptide epitope in the variable region or binding domain of the immunoglobulin. The epitope-containing immunoglobulins are useful in treating such diseases as autoim- mune disorders, as the epitoge inserted into the binding domain of the immunoglobulin is capable of inducing or preventing sen- sitization of the host to that epitope.

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