A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/136 (2006.01) A61K 31/737 (2006.01) A61K 45/06 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 31/00 (2006.01) A61P 31/22 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2761628
The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.
La présente invention concerne l'utilisation nouvelle et surprenante de l'acide hyaluronique sulfaté (HAS) comme agent de régulation de l'activité cytokinique (pro- et anti- inflammatoire) et par conséquent l'utilisation de HAS pour la préparation d'un nouveau médicament à usage topique destiné à la prévention et au traitement de pathologies associées à l'activation des cytokines et/ou à la déficience en cytokines de nature pro- et anti- inflammatoire. Le demandeur a en fait découvert l'aptitude exclusive de HAS à moduler l'activité de ces protéines particulières, a étudié son mécanisme d'action et a démontré la différence sensible entre les différents types sulfatés connus dans l'état de l'art, mais a démontré par-dessus tout une activité élevée inattendue de HAS contre différents types et différentes souches d'herpèsvirus, de cytomégalovirus et de virus de la stomatite vésiculaire. Enfin, la présente invention concerne également l'utilisation de HAS comme promoteur d'absorption cutanée de médicaments de nature anti-inflammatoire.
D'este Matteo
Gennari Giovanni
Fidia Farmaceutici S.p.a.
Kirby Eades Gale Baker
LandOfFree
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