Reagents and treatment methods for autoimmune diseases

Details Reagents and treatment methods for autoimmune diseases Reagents and treatment methods for autoimmune diseases

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2476776

The invention concerns treatment methods using anti-CD22 monoclonal antibodies with unique physiologic properties. In particular, the invention concerns methods for the treatment of B-cell malignancies and autoimmune diseases by administering an effective amount of a blocking anti-CD22 monoclonal antibody specifically binding to the first two Ig-like domains, or to an epitope within the first two Ig-like domains of native human CD22 (hCD22).

L'invention concerne des méthodes thérapeutiques utilisant des anticorps monoclonaux anti-CD22 faisant preuve de propriétés physiologiques uniques. L'invention concerne plus particulièrement des méthodes thérapeutiques de tumeurs malignes associées aux lymphocytes B et de maladies auto-immunes par administration d'une quantité efficace d'un anticorps monoclonal anti-CD22 de blocage spécifiquement lié aux deux premiers domaines de type Ig ou à un épitope se trouvant dans les deux premiers domaines de type Ig de CD22 humain natif (hCD22).

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