Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2453248

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

La présente invention concerne des compositions et des techniques de thérapie et de diagnostic du cancer, et en particulier du cancer du sein. Des compositions de cette invention comprennent un ou plusieurs polypeptides de tumeur de sein, des parties immunogènes de ceux-ci, des polynucléotides codant pour ces polypeptides, des cellules présentant des antigènes qui expriment ces polypeptides et des lymphocytes T spécifiques de cellules exprimant ces polypeptides. Ces compositions conviennent, par exemple, pour le diagnostic, la prévention et/ou le traitement de maladies, et en particulier le cancer du sein.

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