A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/42 (2006.01) A61K 39/395 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) C07K 16/10 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2704119
A CDR grafted humanized recombinant antibody against infection from Venezuelan equine encephalitis virus (VEEV) comprises a human Ig framework having CDRs from murine mAb 1A4A1 VH and VL. DNA sequences, expression vectors incorporating such sequences and transformed host cells are also provided. Also provided are pharmaceutical compositions and methods of prophylaxis and treatment against VEEV infection using the humanized recombinant antibodies of the invention.
L'invention porte sur un anticorps humanisés de recombinaison greffé par CDR contre le virus de l'encéphalite équine du Vénézuéla (VEEV) comprenant une structure d'ig humaine présentant les CDRs murins mAb 1A4A1 VH et VL. L'invention porte également sur des séquences d'ADN, des vecteurs d'expression incorporant lesdites séquences et des cellules hôtes transformées. L'invention porte en outre sur des préparations pharmaceutiques, des méthodes prophylactiques et des traitements, contre les infections par le VEEV, utilisant les anticorps humanisés de recombinaison de l'invention.
Hu Wei-Gang
Nagata Leslie P.
Blake Cassels & Graydon Llp
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence
LandOfFree
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