Peptide inhibitors of the serine protease activity...

Details Peptide inhibitors of the serine protease activity... Peptide inhibitors of the serine protease activity...

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) A61K 38/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319306

Subject of the invention are peptides capable of inhibiting the serine- protease activity associated to the NS3 protein of HCV virus, their uses and a process for their production comprising the proteolysis of polypeptides containing at least one among the sequences of the NS3/NS4A, NS4A/NS4B, NS4B/NS5A and/or NS5A/NS5B junction sites of the polyprotein of HCV virus.

L'invention concerne des peptides capables d'inhiber l'activité de la sérine protéase associée à la protéine NS53 du virus de l'hépatite C (VHC), leurs utilisations et leur procédé de production consistant à effectuer la protéolyse de polypeptides contenant au moins une séquence sélectionnée parmi les sites de jonction NS3/NS4A, NS4A/NS4B, NS4B/NS5A et/ou NS5A/NS5B de la polyprotéine du VHC.

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