C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/296
C07D 213/72 (2006.01) A61K 31/44 (2006.01) C07D 213/73 (2006.01) C07D 213/75 (2006.01)
Patent
CA 2032973
ABSTRACT HOE 89/5 048 K Aminopyridinylmethanols and Aminomethylpyridinamines and Related Compounds The present invention relates to various compounds of the formula I, Image (I), where X is OH, O, NOH, NH2, loweralkylamino, cycloalkylamino, arylloweralkylamino or arylamino; R1 is H, loweralkylcarbonyl, arylcarbonyl, arylloweralkylcarbonyl, loweralkyl or arylloweralkyl; R2 is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl, aryl; and R3 when present is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl with the proviso that, if X is OH or NH2, R1, R2 and R3 may not all be hydrogen; and if X = O, R2 may not be hydrogen and R1 may not be 2,2-dimethylpropionyl; and a process for their preparation. The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease, as topical antiinflammatory agents for the treatment of various dermatoses and also as analgesic agents.
Effland Richard Charles
Klein Joseph Thomas
Aventis Pharmaceuticals Inc.
Bereskin & Parr
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