Naphthalene and isoquinoline derivatives bearing a pyridyl...

Details Naphthalene and isoquinoline derivatives bearing a pyridyl... Naphthalene and isoquinoline derivatives bearing a pyridyl...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 31/444 (2006.01) A61K 31/4418 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/502 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/5415 (2006.01) A61P 3/10 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 43/00 (2006.01) C07D 213/64 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Type

Patent

Patent number

CA 2583492

Description

The present invention relates to use of a pyridine compound of the following formula [I]: (see formula I) wherein R is a substituted pyridyl group having the following formula: (see formula II) or (see formula III) R0 is a C1-6 alkoxy-C1-6 alkyl group, R1 and R2 are the same or different and a C1-6 alkoxy group, X is a group of the formula: =N- or a group of the formula: (see formula IV) Ring A is a saturated or unsaturated 10-membered nitrogen-containing hetero- bicyclic group optionally having a substituent(s), the dotted line means the presence or absence of a double bond, or a pharmaceutically acceptable salt thereof for the preparation of a medicament for treatment of skin lesions.

La présente invention a pour objet l~emploi d'un dérivé de pyridine de formule [I] suivante, ou d~un sel de qualité pharmaceutique de ce composé, dans la préparation d~un médicament pour le traitement de lésions cutanées : où R est un groupement pyridyle substitué de formule : R0 représente un groupement alcoxy en C1-C6 - alkyle en C1-C6, R1 et R2 représentent chacun un groupement alcoxy en C1-C6, ces deux groupements pouvant être différents l~un de l~autre, et X est un groupement de formule : =N- ou de formule : , le Cycle A est un groupement hétérocyclique bicyclique azoté saturé ou insaturé à 10 chaînons éventuellement substitué par un ou plusieurs groupements, les lignes pointillées signifiant la présence possible d'une double liaison.

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