Poly(dipeptide) as a drug carrier

Details Poly(dipeptide) as a drug carrier Poly(dipeptide) as a drug carrier

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61K 31/337 (2006.01) A61K 45/00 (2006.01) A61K 45/08 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2369029

A novel polypeptide drug carrier is provided wherein polypeptides containing glutamic acid and aspartic acid, or glutamic acid/alanine, or glutamic acid/asparagine, or glutamic acid/glutamine, or glutamic acid/glycine, are conjugated to drugs in order to improve the solubility of the drugs and/or their therapeutic efficacy in vivo. An illustrative example involves the conjugation of paclitaxel to a poly(glutamic acid/aspartic acid) polypeptide and its efficacy in the treatment of prostate cancer in vivo.

Cette invention concerne un nouveau vecteur polypeptidique de médicament dans lequel des polypeptides renfermant de l'acide glutamique et de l'acide aspartique, ou de l'acide glutamique/alanine, ou de l'acide glutamique/asparagine, ou de l'acide glutamique/glutamine, ou de l'acide glutamique/glycine, sont conjugués avec des médicaments afin d'améliorer la solubilité et/ou l'efficacité thérapeutique in vivo desdits médicaments. On citera à titre d'exemple la conjugaison de paclitaxel et d'un poly(acide glutamique/acide aspartique) polypeptide et son efficacité dans le traitement du cancer de la prostate in vivo.

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