C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2432867
The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
La présente invention concerne de nouveaux polynucléotides codant des polypeptides HLRRSI1, des fragments et des homologues correspondants. Cette invention concerne aussi des vecteurs, des cellules hôtes, des anticorps, et des méthodes synthétiques et recombinantes de production desdits polypeptides. Ladite invention a également trait à des méthodes diagnostiques et thérapeutiques d'application de ces nouveaux polypeptides HLRRSI1 dans le cadre du diagnostic, du traitement et/ou de la prévention de diverses maladies et/ou troubles afférents à ces polypeptides, notamment des maladies et/ou troubles gastro-intestinaux. Cette invention se rapporte, en outre, à des méthodes de criblage d'identification d'agonistes et d'antagonistes de polynucléotides et de polypeptides susmentionnés.
Feder John
Mintier Gabe
Ramanathan Chandra
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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