Non-endogenous, constitutively activated human serotonin...

Details Non-endogenous, constitutively activated human serotonin... Non-endogenous, constitutively activated human serotonin...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07D 231/12 (2006.01) C07D 231/16 (2006.01) C07D 409/12 (2006.01) C07K 14/705 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2325559

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT2A and human 5-HT2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT2A receptors.

L'invention porte sur: des formes non endogènes à activité constitutive des récepteurs humains 5-HT¿2A? et 5 HT¿2C? et leur utilisation pour le criblage de composés candidats; sur des composés candidats identifiés par le procédé de criblage utilisant les récepteurs 5-HT¿2A?; et sur une nouvelle classe de composés agissant sur les 5-HT¿2A?.

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