Bicyclopolyazamacrocyclophosphonic acid complexes, a process...

Details Bicyclopolyazamacrocyclophosphonic acid complexes, a process... Bicyclopolyazamacrocyclophosphonic acid complexes, a process...

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07F 9/547 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07K 1/13 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C08B 37/02 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2103555

2103555 9311801 PCTABS00022 Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes. Processes for preparing the complex and conjugate are discussed.

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