C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61P 31/04 (2006.01) C07K 14/235 (2006.01) C07K 16/12 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2415238
The present invention discloses polypeptides for use in vaccines against pertussis and parapertussis. The polypeptides of the invention are derived from the Bordetella pertussis pertactin. Preferably, the polypeptides of the invention comprise sequences from region 1 of pertactin, in particular they comprise one or more "GGFGP" or "GGAVP" repeats. Alternatively the polypeptides of the invention have a pertactin sequence from which part or all of region 1 or region 2 is deleted. The polypeptides of the invention are incorporated in compositions that are useful as vaccines for human and veterinary purposes. The invention further discloses antibodies against the pertactin-derived polypeptides of the invention.
L'invention concerne des polypeptides à utiliser dans des vaccins contre pertussis et parapertussis. Les polypeptides sont dérivés de la pertactine de Bordetella pertussis et comprennent de préférence des séquences de la région 1 de pertactine. Ils comprennent notamment une ou plusieurs séquences de répétition de <= GGFGP >= ou <= GGAVP >=. Les polypeptides de l'invention comportent éventuellement une séquence de pertactine de laquelle est délétée une partie ou la totalité de la région 1 ou de la région 2. Les polynucléotides sont incorporés à des compositions utiles comme vaccins humains et vétérinaires. L'invention concerne également des anticorps dirigés contre les polypeptides dérivés de la pertactine.
Ridout & Maybee Llp
Volksgezondheid En Cultuur de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W
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