Stabilized protein preparation and process for its preparation

Details Stabilized protein preparation and process for its preparation Stabilized protein preparation and process for its preparation

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) A61K 38/36 (2006.01) A61K 38/38 (2006.01) A61K 38/39 (2006.01) A61K 38/57 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) C07K 14/76 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2346616

A stabilized protein preparation is described which contains no antithrombin III and is protected against a loss of action during pasteurization by the addition of stabilizers which consist of one or more saccharides as a mixture with more than 0.5 mol/l of one or more amino acids from the group arginine, lysine, histidine, phenylalanine, tryptophan, tyrosine, aspartic acid and its salts or glutamic acid and its salts, where glycine and/or glutamine can also be additionally added to each of these amino acids. A process for the viral inactivation or viral depletion of a protein preparation of this type which contains the abovementioned stabilizers and is subjected to pasteurization or viral depletion by filtration, centrifugation or treatment with detergents or bactericidal or virucidal agents is moreover described.

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