Compounds and methods for the stimulation and enhancement of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/30 (2006.01) A61K 38/16 (2006.01) A61K 39/008 (2006.01) C07K 14/44 (2006.01) C07K 16/20 (2006.01) C12N 5/08 (2006.01) C12Q 1/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2188543

Compounds and methods for stimulating and enhancing immune responses and for evaluating patient immune responses are disclosed. Disclosed compounds include polypeptides that contain at least a biologically active portion of a Leshmania brazillensis homolog of the eukaryotic initiation factor 4A, or a variant thereof. Such compounds are useful for stimulating a Th1 immune response and IL-12 production in patients, as well as in isolated cells and cell cultures. The polypeptides of this invention are further useful for the evaluation and treatment of patients, who may be afflicted with leishmaniasis or other disorders.

Composés et méthodes destinés à stimuler et à améliorer les réponses immunitaires et à évaluer les réponses immunitaires de patients. Les composés décrits comprennent des polypeptides qui contiennent au moins une partie biologiquement active d'un homologue Leishmania braziliensis du facteur d'initiation eucaryote 4A, ou une variante de ladite partie. Lesdits composés sont utiles pour stimuler une réponse immunitaire Th1 et la production d'interleukine-12 (IL-12) chez des patients, ainsi que dans des cellules isolées et des cultures cellulaires. Les polypeptides de la présente invention sont en outre utiles pour évaluer et traiter des patients qui peuvent être atteints de leishmaniose et d'autres troubles.

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