Ex vivo oxidatively stressed cll cells in chronic...

A - Human Necessities – 61 – K

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A61K 41/00 (2006.01) C12N 5/071 (2010.01) A61K 35/14 (2006.01) A61P 35/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2436515

Chronic lymphocytic leukemia (CLL) in a patient is treated by administering to the patient oxidatively stressed CLL cells. The CLL cells are oxidatively stressed extracorporeally, e.g. by subjection to oxygen/ozone mixtures, and preferably are simultaneously subjected to other stressors such as UV light. Preferably also, the CLL cells are autologous, and are contained in an aliquot of the patient's blood at the time of subjection to stressing.

L'invention concerne un traitement de la leucémie lymphoïde chronique (LLC) consistant à administrer au patient des cellules LLC qui ont été soumises à un stress oxydatif. Ce stress oxydatif est provoqué dans cellules LLC de manière extracorporelle, p. ex. par exposition des cellules à des mélanges oxygène/ozone, les cellules étant de préférence soumises simultanément à d'autres facteurs de stress tels qu'une lumière U.V. Les cellules LLC sont de préférence des cellules autologues, et sont contenues dans une aliquote de sang du patient au moment où elles sont soumises au stress.

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