A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2383773
The present invention provides methods and compositions for treating auto- immune disease. The methods of the present invention comprise administering to a mammal diagnosed with an auto-immune disease a synergistic ratio of (i) an agent that regulates ICAM-LFA-1 interaction, and (ii) an agent that regulates CD40-CD40 ligand interaction. The compositions of the present invention comprise a synergistic ratio of (i) an agent that regulates ICAM-LFA-1 interaction, and (ii) an agent that regulates CD40-CD40 ligand interaction.
La présente invention concerne des méthodes et des compositions destinées au traitement des maladies auto-immunes. Les méthodes selon la présente invention consistent à administrer à un mammifère chez lequel on a diagnostiqué une maladie auto-immune un rapport synergique (i) d'un agent régulant l'interaction ICAM-LFA-1, et (ii) d'un agent régulant l'interaction des ligands CD40-CD40. Les compositions selon la présente invention renferment un rapport synergique (i) d'un agent régulant l'interaction ICAM-LFA-1, et (ii) d'un agent régulant l'interaction des ligands CD40-CD40.
Souza Donald J.
Boehringer Ingelheim Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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