Taxol as a radiation sensitizer

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/335 (2006.01) A61K 41/00 (2006.01) A61K 51/12 (2006.01) A61N 5/10 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2128693

2128693 9314787 PCTABS00024 This invention provides a method of increasing sensitivity of cells to cytotoxic effects of ionizing radiation which includes incubating the cells with spindle poison in suitable carrier at a concentration effective to inhibit the cells from progressing through G2 or M phases of the cell cycle for a time effective to inhibit division of the cells and then administering a cytotoxic dose of ionizing radiation to the cells. This invention also provides a method of treating a cancer patient which comprises administering to patient a spindle poison in suitable carrier in an amount effective to inhibit tumor cells in the patient from progressing through G2 or M phases of the cell cycle for an amount of time effective to inhibit division of the tumor cells and then administering a cytotoxic dose of ionizing radiation to the patient. This invention further provides a method for increasing the sensitivity of cells to bleomycin and a kit useful for treating cancer patients.

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