Use of oligonucleotides with modified bases in hybridization...

Details Use of oligonucleotides with modified bases in hybridization... Use of oligonucleotides with modified bases in hybridization...

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2704560

The invention is concerned with the use of oligonucleotide analogs that contain specifically modified DNA bases to be used in hybridization of nucleic acids, polymerase chain reaction (PCR) and siRNA-mediated gene silencing (RNAi).

L'invention concerne l'utilisation d'analogues d'oligonucléotides qui contiennent des bases d'ADN modifiées de façon spécifique pour être utilisées dans l'hybridation d'acides nucléiques, la réaction en chaîne par polymérase (PCR) et pour faire taire les gènes à médiation par l'ARNsi (ARNi).

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