Use of bi-specific antibodies for pre-targeting diagnosis...

Details Use of bi-specific antibodies for pre-targeting diagnosis... Use of bi-specific antibodies for pre-targeting diagnosis...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2690395

The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.

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