Endothelin antagonists

Details Endothelin antagonists Endothelin antagonists

C - Chemistry, Metallurgy

07

D

C07D 317/60 (2006.01) A61K 31/195 (2006.01) A61K 31/36 (2006.01) A61K 31/395 (2006.01) A61K 31/66 (2006.01) C07C 59/64 (2006.01) C07C 65/24 (2006.01) C07C 311/51 (2006.01) C07D 317/62 (2006.01) C07D 317/64 (2006.01) C07D 405/02 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 473/00 (2006.01) C07F 9/40 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2167410

Novel derivatives of general structural formula (I) have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, complications of diabetes, migraine, bone resorption, and inflammatory diseases, including Raynaud's disease and asthma.

De nouveaux dérivés représentés par la formule structurale générale (I) présentent une activité antagoniste vis-à-vis de l'endothéline et sont pour cela utiles dans le traitement d'affections cardio-vasculaires telles que l'hypertension artérielle, l'hypertension artérielle pulmonaire, l'insuffisance rénale postischémique, l'angiospasme, l'ischémie cérébrale et cardiaque, l'infarctus du myocarde, le choc endotoxique, l'adénome prostatique, les complications du diabète, la migraine, la résorption osseuse et des maladies inflammatoires, y compris la maladie de Raynaud et l'asthme.

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