Mutant interleukin 6 with improved biological activity over...

Details Mutant interleukin 6 with improved biological activity over... Mutant interleukin 6 with improved biological activity over...

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2129824

Mutant interleukin 6, characterized by the fact that it has, in the position 176, the amino-acid arginine in place of the ami- no-acid serine as in wild interleukin 6, and by the fact that it shows greater biological activity than wild interleukin 6. The figure represents the genetic map of the plasmid pBKS IL-6 Ser176Arg containing the nucleotidic sequence coding for mutant interleu- kin 6 according to the invention, non-glycosilated. This plasmid has been filled in E. coli K12 with the National Collection of In- dustrial and Marine Bacteria Ltd. on 02/11/1992 under access number NCIMB 40526.

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