Thiazol-2-yl-imine compounds as pde-7 inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 417/04 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 37/00 (2006.01) C07D 277/42 (2006.01)

Patent

CA 2480568

A compound selected from those of formula (I), wherein: R1, R2, R3 are as defined in the description, and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as inhibitors of phosphosdiesterase-7.

Cette invention porte sur un composé sélectionné parmi ceux représentés par la formule (I) dans laquelle : R¿1?, R¿2? et R¿3? désignent des groupes définis dans la description et éventuellement les isomères optiques, un N-oxyde et des sels d'addition de ces groupes avec un acide ou une base pharmaceutiquement acceptables et porte également sur des produits médicinaux contenant ces composés et servant d'inhibiteurs de la phosphodiestérase-7.

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