Pharmaceutical compositions of the isolated d- enantiomer of...

Details Pharmaceutical compositions of the isolated d- enantiomer of... Pharmaceutical compositions of the isolated d- enantiomer of...

A - Human Necessities

61

K

A61K 31/52 (2006.01) A01N 43/90 (2006.01)

Patent

CA 2600046

The present invention relates to pharmaceutical compositions comprising as an active ingredient an isolated, chirally pure D-enantiomer of the quinazolinone derivative halofuginone having increased therapeutic activity and decreased side effects compared to the corresponding racemic mixtures, the composition being substantially free of the L-enantiomer and useful in the treatment of diseases and disorders associated with fibrotic conditions or cell proliferation.

La présente invention concerne une composition pharmaceutique comprenant comme principe actif un énantiomère D isolé de dérivé de quinazolinone halofuginone possédant une activité thérapeutique accrue et des effets secondaires moindres comparés aux mélanges racémiques correspondants, cette composition étant sensiblement exempte d'énantiomère L et convenant pour le traitement de maladies et de troubles associés aux états fibreux ou à la prolifération cellulaire.

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