Derivatives of substituted imidazol-2-one and process for...

C - Chemistry – Metallurgy – 07 – D

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C07D 453/02 (2006.01) A61K 31/44 (2006.01) C07D 451/00 (2006.01) C07D 451/04 (2006.01) C07D 451/14 (2006.01)

Patent

CA 2062271

Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2- ones are provided of general formula (I) Image in which inter alia R3 represents a group (see formula I and II) wherein n is an integer of 1 or 2 and R8 is hydrogen, C1-C6 alkyl unsubstituted or substituted by phenyl, C2-C4 alkenyl, C2-C4 alkynyl, formyl or C2-C6 alkanoyl; and the pharma- ceutically acceptable salts thereof, which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addition agents and analgesic.

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