Compositions of iodophenoxy alkylene ethers for...

Details Compositions of iodophenoxy alkylene ethers for... Compositions of iodophenoxy alkylene ethers for...

C - Chemistry, Metallurgy

07

C

C07C 43/225 (2006.01) A61K 49/04 (2006.01) C07C 69/94 (2006.01) C07C 69/96 (2006.01) C07C 255/54 (2006.01)

Patent

CA 2115816

ABSTRACT OF THE DISCLOSURE Disclosed are novel iodophenoxy alkylene ethers of the formula: Image [wherein Z is H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl or cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R is C1-C25 alkyl, cycloalkyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy-carbonyl or lower-alkoxy- carbonyloxy, (CR1R2)p-(CR3=CR4)mQ, (CR1R2)p-C?C-Q or Image ; R1, R2, R3 and R4 are independently H, lower-alkyl, optionally substituted with halo; x and x' are 1-4; n and n' are 1-4; m is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, aryl or aryl-lower-alkyl] useful as contrast agents in diagnostic radiology of the gastrointestinal tract.

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