Phenolic thioetheramides as 5-lipoxygenase inhibitors

Details Phenolic thioetheramides as 5-lipoxygenase inhibitors Phenolic thioetheramides as 5-lipoxygenase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 211/16 (2006.01) C07D 213/40 (2006.01) C07D 295/185 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2088503

2088503 9204324 PCTABS00011 The present invention relates to phenolic thioetheramides of formula (I) wherein R1 and R2 are tert-alkyl or phenyl, Alk1 and Alk2 are alkylene; X is sulfer or oxygen, m is 0, 1, or 2; and R is a) wherein R3 and R4 are hydrogen or alkyl and Alk3 is alkylene; or b) wherein Y is CH, N, O, or S; R6 is hydrogen, alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl or a heterocyclic amine; and R7 is hydrogen or alkyl. The compounds inhibit 5-lipoxygenase and are useful in the treatment of inflammation and allergic conditions.

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