Method for attenuating virulence of microbial pathogens and...

A - Human Necessities – 61 – K

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Details

A61K 31/7084 (2006.01) A61P 1/12 (2006.01) A61P 31/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2533873

The present invention relates to the use of the cyclic dinucleotide c-di-GMP and cyclic dinucleotide analogues thereof in a method for attenuating virulence of a microbial pathogen or for inhibiting or reducing colonization by a microbial pathogen. This method further inhibits microbial biofilm formation and is capable of treating bacterial infections. The microbial colonization or biofilm formation inhibited or reduced may be on the skin or on nasal or mucosal surface. The microbial colonization or biofilm formation inhibited can also be on the surfaces of medical devices, especially those in close contact with the patient, as well on the surfaces of industrial and construction material where microbial colonization and biofilm formation is of concern.

La présente invention se rapporte à l'utilisation de c-di-GMP dinucléotidique cyclique et à ses analogues dinucléotidiques cycliques pour la mise en oeuvre d'un procédé permettant d'atténuer la virulence d'un agent pathogène microbien ou permettant d'inhiber ou de réduire la colonisation par un agent pathogène microbien. Ce procédé inhibe par ailleurs la formation d'un biofilm microbien et permet le traitement d'infections bactériennes. La colonisation microbienne ou la formation d'un biofilm microbien inhibée ou réduite peut concerner la surface de la peau ou une surface des voies nasales ou de muqueuses. La colonisation microbienne ou la formation d'un biofilm microbien inhibée peut également concerner les surfaces de dispositifs médicaux, notamment ceux en contact étroit avec un patient, ainsi que les surfaces de matière industrielle et de construction pour lesquelles une colonisation microbienne ou la formation d'un biofilm microbien constitue une inquiétude.

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