Treating neoplasms with neurotoxin

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 39/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2744823

The present invention provides a method of treating a neoplasm using a neurotoxin, preferably botulinum toxin. Neurotoxin administered around a neoplasm acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze neoplastic cells through efferent channels leaving the neoplasm to distant sites. The present invention also provides a method of administering botulinum toxin at sites distant from the neoplasm, thereby enhancing cellular and humoral immunologic functions, which further contribute to neoplastic cell death. Following administration of botulinum toxin around or distant to a neoplasm as described herein, local, regional, and distant spread of neoplastic cells is reduced or eliminated. Immunomodulation with botulinum toxin is also valuable in treating other diseases that may or may not be associated with cancers, such as viral-induced growths, viral conditions, fungal disease, chronic wounds, graft versus host disease, autoimmune disease, and HIV.

La présente invention concerne un procédé de traitement dun néoplasme utilisant une neurotoxine, de préférence la toxine botulique. La neurotoxine administrée autour dun néoplasme agit de façon à diminuer les forces contractiles des muscles entourant un néoplasme qui pressent normalement les cellules néoplasiques à travers des canaux efférents de manière à quitter le néoplasme vers des sites distants. La présente invention concerne en outre un procédé dadministration de toxine botulique à des sites distants du néoplasme, de manière à renforcer les fonctions immunologiques cellulaires et humorales, qui contribuent plus avant à la mort des cellules néoplasiques. Après administration de la toxine botulique autour ou à distance dune néoplasie comme présentement décrit, la propagation locale, régionale, et distante de cellules néoplasiques est réduite ou éliminée. Limmunomodulation avec la toxine botulique est également utile dans le traitement dautres maladies qui peuvent être ou non associées à des cancers, telles que des croissances induites par un virus, des affections virales, une maladie fongique, des plaies chroniques, une réaction de greffe contre hôte, une maladie auto-immune, et le VIH.

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