C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/280, 260/305
C07D 233/56 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/485 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07C 17/16 (2006.01) C07D 233/84 (2006.01) C07D 319/20 (2006.01) C07D 403/06 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1146549
ABSTRACT OF THE INVENTION Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: Image (I) wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalky- loxy, arylhydroxymethylene, arylcarbonyl, arylalkyl- carbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or (ii) A is an -SO2- group and R is aryl or heterocyclyl or (iii) A is a chemical bond and R is a heterocyclyl or substituted phenyl group, or (iv) A is an aliphatic hydrocarbon residue of from 1 to 3 carbon atoms and R is a halophenyl group. Some of these imidazoles and salts are novel. Methods of preparing the imidazoles are disclosed The imidazoles and their salts are useful in the treat- ment or prophylaxis of thrombo-embolic conditions.
320640
Sherman
Wellcome Foundation Limited (the)
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