Increased t-cell tumor infiltration by mutant light

Details Increased t-cell tumor infiltration by mutant light Increased t-cell tumor infiltration by mutant light

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2529058

Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocites. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and reduced metastasis-using mutant LIGHT are disclosed.

L'expression du Mutant LIGHT dans un environnement tumoral provoque des niveaux de chimiokines et de molécules d'adhésion élevés, ainsi qu'une infiltration massive de lymphocytes T naïfs. L'invention concerne des procédés et des compositions permettant de provoquer des réactions immunitaires contre des tumeurs, notamment la réduction du volume de la tumeur et de métastases au moyen du mutant LIGHT.

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