Process for preparing 2,4,5-trifluorobenzoic acid

Details Process for preparing 2,4,5-trifluorobenzoic acid Process for preparing 2,4,5-trifluorobenzoic acid

C - Chemistry, Metallurgy

07

C

260/513.5

C07C 51/363 (2006.01) C07C 63/70 (2006.01)

Patent

CA 2010158

CASE 5787 ES/ASC/rag 02/06/1989 PROCESS FOR PREPARING 2,4 5-TRIFLUOROBENZOIC ACID Abstract of the Disclosure 2,4,5-Trifluorobenzoic acid is prepared by converting 4,5-di- fluoroanthranilic acid to the corresponding amine salt, converting the amine salt to the corresponding diazonium tetrafluoroborate and decomposing the tetrafluoroborate in a Schiemann reaction. In a preferred preparation, the 10 percent HCl is added to solid 4,5-difluoroanthranilic acid in sufficient amount to dissolve the solid at 70°C, the amine salt is isolated, aqueous NaNO2 is added to the isolated amine salt at 0°C, followed by addition of 40 to 50 percent aqueous HBF4 at 0°C, followed by separation of the tetra- fluoroborate by cooling and filtering and then drying, and the dried separated tetrafluoroborate is thermally degraded to 2,4,5- trifluorobenzoic acid by heating at 125 to 140°C.

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