Method of inducing an immune response

Details Method of inducing an immune response Method of inducing an immune response

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2712056

A method is provided for inducing or enhancing an immune response in a mammal to a target polypeptide expressed in a plurality of cells of the mammal, which method comprises administering to the mammal an inhibitory nucleic acid which targets a region of a ribonucleic acid (RNA) which encodes said polypeptide. Also provided is a pharmaceutical composition comprising an inhibitory nucleic acid which targets a region of an RNA which encodes a target polypeptide expressed in a plurality of cells of a mammal, such that translation of an aberrant form of the target polypeptide occurs in said cells, said truncated form of the target polypeptide comprising one or more T cell epitopes; together with a pharmaceutically acceptable carrier or diluent.

L'invention concerne une méthode pour induire ou améliorer une réponse immunitaire chez un mammifère par rapport à un polypeptide cible exprimé dans une pluralité de cellules du mammifère. Ladite méthode consiste : à administrer au mammifère un acide nucléique inhibiteur qui cible une région d'acide ribonucléique (ARN) codant pour ledit polypeptide. L'invention concerne également une composition pharmaceutique comprenant un acide nucléique inhibiteur qui cible une région d'ARN codant pour un polypeptide cible exprimé dans une pluralité de cellules du mammifère, de sorte qu'il se produit une translation d'une forme aberrante du polypeptide cible dans les cellules, la forme troncaturée du polypeptide cible comprenant un ou plusieurs épitopes de lymphocyte T. L'invention concerne également un excipient ou un diluant pharmaceutiquement acceptable.

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