Compositions and methods for the delivery of oxygen

Details Compositions and methods for the delivery of oxygen Compositions and methods for the delivery of oxygen

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 14/00 (2006.01) C07K 14/195 (2006.01) C07K 14/33 (2006.01) C07K 14/47 (2006.01) C07K 17/08 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C07K 14/805 (2006.01)

Patent

CA 2653080

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O2 is beneficial.

Selon la présente invention, les protéines H-NOX mutent de façon à présenter des propriétés cinétiques et thermodynamiques améliorées ou optimales pour l'administration d'O2 dans le sang. Les protéines H-NOX transformées comprennent des mutations qui donnent une liaison altérée à un ligand O2 ou NO par rapport au domaine de H-NOX de type sauvage correspondant, et peuvent fonctionner en tant que véhicules physiologiquement compatibles de gaz O2 dans le sang chez un mammifère. L'invention propose également des compositions pharmaceutiques, des kits et des procédés utilisant des protéines H-NOX de type sauvage ou mutante pour le traitement d'une quelconque condition pour laquelle l'administration de O2 est bénéfique.

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