C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/515.3, 260/4
C07C 51/14 (2006.01) C07C 45/50 (2006.01) C07C 45/65 (2006.01) C07C 49/796 (2006.01) C07C 59/84 (2006.01) C07C 67/38 (2006.01) C07C 69/738 (2006.01)
Patent
CA 2028818
This Invention provides a method of producing highly pure .alpha.-(3-benzoylphenyl)propionic acid derivatives, which are medicines per se or which can easily afford the same, from readily available 3-ethylbenzophenone in a very simplified manner efficiently and economically. The Method comprises dehydrogenating 3-ethylbenzophenone in vapor phase in the presence of an inert gas and carbonylating the formed 3-ethenylbenzophenone in the presence of a carbonylation catalyst comprising a transition metal complex.
Procédé très simple, efficient et économique de production de dérivés de l'acide alpha-(3-benzoylphényl)propionique, qui constituent des produits pharmaceutiques en soi ou qui permettent d'en produire facilement, à partir de 3-éthylbenzophénone, composé aisément disponible. Le procédé consiste à déshydrogéner du 3-éthylbenzophénone en phase de vapeur en présence d'un gaz inerte et à carbonyler le 3-éthénylbenzophénone ainsi formé en présence d'un catalyseur de carbonylation comprenant un complexe métallique de transition.
Inomata Yoshihisa
Matsumura Yasuo
Shimizu Isoo
Gowling Lafleur Henderson Llp
Nippon Petrochemicals Company Limited
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