Diamine derivatives having selective affinity for sigma...

Details Diamine derivatives having selective affinity for sigma... Diamine derivatives having selective affinity for sigma...

C - Chemistry, Metallurgy

07

C

C07C 233/35 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) C07C 211/27 (2006.01) C07C 233/36 (2006.01) C07C 233/37 (2006.01) C07C 233/40 (2006.01) C07C 255/58 (2006.01) C07C 311/00 (2006.01) C07C 313/06 (2006.01) C07C 317/26 (2006.01) C07C 323/63 (2006.01) C07D 207/325 (2006.01) C07D 295/125 (2006.01) C07D 295/13 (2006.01)

Patent

CA 2112490

ABSTRACT OF THE DISCLOSURE Diamine derivatives of formula (I), wherein n = 0-8; R1 is hydrogen or a C1-3 alkyl residue; each of R2, R3, R4, R5 and R6 is hydrogen, a C1-6 alkyl residue, branched C4-12 alkyl or alkenyl: R2 and R3 together may form a C3-8 ring optionally including a heteroatom and optionally partially or wholly unsatured; R5 and R6 taken together may form a C2-8 ring; X is a single bond, -CH2-, -C (=O)-, -S(O)-, or -S(O)2-: Y is an alkyl residue, cycloalkyl, cycloalkylalkyl, adamantyl, optionally substituted phenyl or an aromatic heterocyclic ring: Ar is an optionally substituted phenyl radical, naphtyl or an aromatic heterocyclic ring. Said derivatives are psychotropic agents particularly suitable for treating psychotic disorders, convulsion, dyskinesia, brain distress (ischaemia, hypoxia) and anxiety, and further have anti-inflammatory properties.

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